Anaphylaxis: Anaphylaxis is reported with codeine, on the list of substances in promethazine HCl and codeine phosphate oral Alternative.The opioid antagonists, naloxone and nalmefene, are precise antidotes for respiratory depression ensuing from opioid overdose. For clinically considerable respiratory or circulatory melancholy secondary to codeine

, ritonavir) or discontinuation of a cytochrome P450 3A4 inducer for example rifampin, carbamazepine, and phenytoin, could bring about a rise in codeine plasma concentrations with subsequently higher metabolism by cytochrome P450 2D6, resulting in increased morphine levels, which could maximize or prolong adverse reactions and may induce most likel